Once the experimental system was validated, we created cellular models either overexpressing ALDH3A1 in WM cells (3A1high), or silencing ALDH3A1 in WM and HCC cells (3A1low clones Sh #1 and #2) compared to cells with an empty vector (Ctr) (Supplementary Figure S1a–c). The gene discussed is ALDH3A1; the disease is hepatocellular carcinoma.