In agreement with literature data demonstrating that PGE-2 by tumor cells influences the expression and release of immunosuppressive cytokines [21], we found that ALDH3A1 silencing selectively reduced immunosuppressive cytokines (Figure 4c), and increased the production of immune-stimulating ones (Figure 4c and Supplementary Tables S1 and S2). This evidence concerns the gene ALDH3A1 and neoplasm.