Additionally, when we analyzed the COX-2 expression in relation to ALDH3A1, we found 11 positive cases out of 13 (84.6%) for lung adenocarcinoma and six positive cases out of seven (85.7%) for skin melanoma, with high H scores for both ALDH3A1 and COX-2 (Figure 8 and Supplementary Table S4). Here, ALDH3A1 is linked to lung adenocarcinoma.