A number of studies have documented curcumin mediated anti-proliferative effect in lung cancer cells via modulation of various molecular targets such as STAT-3, EGFR, Forkhead Box O3 (FOXO3a), Eukaryotic Initiation Factors (eIFs), and Transforming Growth Factor-Beta (TGF-β). This evidence concerns the gene STAT3 and lung cancer.