NAMPT and cancer: Visfatin can increase cell adhesion ability [8,9,10,11], and intracellular cancer cell visfatin has been shown to increase cell proliferation through Protein kinase B(Akt) /phosphoinositide 3-kinases (PI3K) and extracellular-signal-regulated kinase/ mitogen activated protein kinase (ERK/MAPK) activation [12].