Pre-clinical studies using cell and mouse models demonstrated the efficacy of dual PI3K/mTOR inhibitors such as BEZ235 or dactolisib (NVP-BEZ235, Novartis) in several types of cancers including breast cancer, lung adenocarcinomas, glioblastoma, [209,210,211]. The gene discussed is MTOR; the disease is glioblastoma.