For example, in diffuse large B cell lymphoma (DLBCL) wherein about 40% are refractory to the standard combined immunotherapy (R-CHOP), the low levels of GAPDH, which predict poor response to R-CHOP, correlated with dependence on oxidative phosphorylation (OxPhos) metabolism, mTORC1 signaling and glutaminolysis. The gene discussed is DDIT3; the disease is diffuse large B-cell lymphoma.