NF2 and neurofibromatosis: In neurofibromatosis type 2 (NF2) disorder, which is characterized by multiple tumors in the central nervous system such as schwannomas and meningiomas, the deficiency of the Nf2 gene, which encodes the tumor suppressor Merlin, upregulated mTORC1 leading to elevated expression of key enzymes involved in lipogenesis.