We show here the association between Notch expression and cytogenetic risk, by demonstrating the overexpression of Notch3, Notch 4, and Jagged 2 in cell samples from AML patients belonging to adverse cytogenetic groups, while these molecules were lacking in control cells, such as CD34+ cells and peripheral blood mononuclear cells (data not shown). The gene discussed is NOTCH4; the disease is acute myeloid leukemia.