Moreover, the analysis of the HIV-1 gp120 secretion to the extracellular media showed a significant enhancement at early times post-infection in cells infected with MVA-LEO160-gp120, compared to MVA-B-infected cells; confirming that the LEO160 promoter can also enhance the cell release of a soluble antigen, such as HIV-1 gp120. The gene discussed is ITIH4; the disease is infection.