The activities of ASK1 and its downstream target MKK4/7 are induced by DUSP9 deficiency and inhibited by DUSP9 overexpression in hepatic steatosis, indicating that DUSP9 regulates the JNK pathway and related metabolic disorders by dephosphorylating ASK1 [80]. The gene discussed is DUSP9; the disease is Hepatic steatosis.