Overall, pathways related to immune response, epithelial-to-mesenchymal (EMT), transcription of hypoxia-inducible factor 1 (Hif-1) targets, renal injury, cell cycle, secretion of xenobiotics, and signalling processes in cancer were significant for Trp53(+/+), Trp53(+/-), and Trp53(-/-) kidneys. Here, TP53 is linked to cancer.