MED12 and neoplasm: There is no doubt that among the factors involved in the tumor degeneration of stem/progenitor cells, the MED12 and HMGA2 genes play an important role, the pathological effect of mutations of which is realized through dysfunction of various metabolic pathways, primarily Wnt/ß-catenin and Wnt/MAPK, and also prolactin and insulin-like growth factor (IGF) [32].