Epidermal growth factor (EGF), heparin-binding epidermal growth factor (HB-EGF), acidic fibroblast growth factor (aFGF), transforming growth factors-α and -β (TGF-α and TGF-β), main fibroblast growth factor (bFGF), and their receptors also play an important role in the development of LM. This evidence concerns the gene FGF1 and lymphangioma.