FERMT3 and myocardial infarction: Western blot analysis of the protein fractions revealed that proteolytic processing of kindlin-3 primarily occurred in those parts of the platelet that are associated with the soluble and cytoskeletal fractions isolated by ultracentrifugation, whereas the platelet structures that are associated with the membrane fraction showed no quantitative differences between the control and myocardial infarction groups (Figure 4A,B).