Xiao et al. found that the miR-10 in cells of human bladder cancer promotes cell migration and invasion, suggesting that miR-10b is likely to be a mediator of obesity and bladder cancer, acting as an oncogene in the miR-10b/KLF4/E-cadherin axis and miR-10b/HOXD10/MMP14 axis [62]. The gene discussed is KLF4; the disease is obesity due to melanocortin 4 receptor deficiency.