This paper delineates retinal and audiological phenotype of ten unrelated homozygotes for the same stop mutation p.Trp3955Ter in USH2A. The observed phenotype was consistent with the previous natural history reports of USH2 syndrome caused by USH2A mutations [30,31,32,33,34,35], i.e., presentation with nyctalopia in the second decade, narrowing of the visual field with age and progression from hyperfluorescent ring to patch and atrophy on fundus autofluorescent imaging Usher syndrome 1 and 2. Here, USH2A is linked to night blindness.