PXDN and early-onset non-syndromic cataract: Indeed, some homozygous mutations in PXDN in humans cause severe inherited eye disorders, such as congenital cataracts, corneal opacity, and developmental glaucoma because of ASD; other recessive mutations in PXDN show a broader phenotype, including ASD, sclerocornea, microphthalmia, hypotonia, and developmental delays [14,15].