As for the mRNA expression of immunomodulatory genes among tumor entities (Figure 6B,C), the immune inhibitory marker PD-L1 was particularly expressed in the MPE Lung-AC group, which was consistent with our IHC results showing that most of the PD-L1 high expression cases (17 out of 19) were found therein (Supplementary Table S2), while in MPE mesothelioma cases, LAG-3 was dominantly expressed. The gene discussed is LAG3; the disease is medical procedure.