IRS1 and Insulin resistance: Reverses the palmitate-induced insulin resistance. Suppresses nuclear factor kappa beta (NF-κB), insulin receptor substrate one (serine 307) (IRS1 (Ser (307) and AMP-activated protein kinase (AKT) phosphorylation and increases serine/threonine kinase AKT activation. Increases the peroxisome proliferator-activated receptor alpha and gamma (PPARα and γ) and carnitine palmitoyltransferase one (CPT1) expression.