Induces cancer cellapoptosis via a mitochondrial-dependent pathway. Downregulates the antiapoptosis-associated molecule B-cell lymphoma 2 (bcl-2) and increases the levels of the apoptosis-associated molecules bcl-2-like protein 4 and tumor protein p53. Affects the expression of apoptotic protease activating factor-1. The gene discussed is BCL2; the disease is cancer.