Protects cardiomyocytes against hyperglycemia-induced shifts in substrate preference and subsequent apoptosis; prevents myocardium apoptosis; modulates key regulators associated with lipid metabolism (Adipoq, Apob, CD36, Cpt1, Pparγ, Srebf1/2, Scd1, and Vldlr), insulin resistance (Igf1, Akt1, Pde3, and Map2k1), inflammation (Il3, Il6, Jak2, Lepr, Socs3, and Tnf13), and apoptosis (Bcl2 and Chuk). This evidence concerns the gene SOCS3 and Hyperglycemia.