In lung cancer, HIF-1α modulates the expression of several isoforms, including GLUT1 and GLUT3, hexokinase (HK) II, hexosephosphate isomerase (HPI), phosphofructokinase (PFK)-L, aldolase (ALD)-A, triosephosphate isomerase (TPI), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphoglycerate mutase (PGAM)-B, enolase (ENO)-α, pyruvate kinase (PYK)-M2 [121]. This evidence concerns the gene TPI1 and lung cancer.