Novel fusions resulting from intra-or inter-chromosomal rearrangements and mostly cytogenetically cryptic involved cancer genes implicated in hematologic malignancy: RUNX1, IKZF1, MECOM, and MSI2. They included RUNX1-MX1, MBNL1-MECOM, and MSI2-PRMT2. This evidence concerns the gene RUNX1 and cancer.