Additionally, PP2A-induced activation of the SHP-1 tyrosine phosphatase has been shown to promote BCR-ABL1 tyrosine dephosphorylation (inactivation) which, in turn, triggers its proteasome-dependent degradation in CML BP progenitor patient cells [98]. The gene discussed is PTPA; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.