BRCA1 and chronic myelogenous leukemia, BCR-ABL1 positive: Reduced BRCA1 protein levels in CML has been ascribed to BCR-ABL1-dependent inhibition of BRCA1 mRNA translation [34] and to BCR-ABL1-dependent downregulation of the BRCA1-associated protein 1 (BAP1) deubiquitinase [35].