In this regard, Jelinek et al. studied the methylation status of promoter-associated CpG island of 10 genes (ABL1, CDH13, DPYS, CDKN2B, OSCIP1, PGR-A, PGR-B, TFAP2E, NPM2, PDLIM4) in CML patients observing a remarkable methylation increase underlying the progression from AP to BP [110]. Here, PDLIM4 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.