MAPT and Alzheimer disease: Some literature exists on the impact of gonadectomy on cognitive function in dogs, most notably regarding Canine Cognitive Dysfunction (CCD), which is a behavioral syndrome affecting older dogs that shares many pathophysiological and behavioral hallmarks with human Alzheimer’s Disease (AD), including progressive cognitive impairment, loss of normal sleep patterns, increased anxiety, and aimless wandering as well as Amyloid-beta and possibly tau pathology in the brain [230,231,232].