NPM1 and Myelodysplasia: According to the 2016 revision of WHO classification of myeloid malignancies [10], our cohort included one AML with inv(16)(p13q22) (sample #84), one AML with mutated NPM1 (sample #63569), one AML without maturation (sample #59810), one AML with maturation (sample #20), one AML with mutated RUNX1 (sample #21) and three AML cases with myelodysplasia-related changes (samples #32, #68187 and #125).