ALOX5AP and chronic myelogenous leukemia, BCR-ABL1 positive: Of note, among genes deregulated in the leukotriene pathway we identified ALOX5 (fold change = −4.36) and ALOX5AP (fold change = −2), where the loss of ALOX5 has been reported to impair leukemic stem cells and prevent the onset of chronic myeloid leukemia in mice [41].