In ALS disease, when p75NTR is decreased at the NMJ [95], it is not able to bind functional TrkB [116,117] which is also decreased [95], and under high doses of neurotrophins, p75NTR acquires a proapoptotic role which goes through the activation of caspase 3 [118,119]. Here, BDNF is linked to amyotrophic lateral sclerosis.