In summary, the reduction, prevention or even overcompensation of the ALS-induced damaging molecular changes in the BDNF/TrkB pathway and the downstream proteins at the NMJ by exercise training [166] adds new molecular evidence of the benefits of physical exercise to reduce the impact of the disease, as these molecular changes are contemporary with improvements in animals’ conditions, where MN loss is reduced. Here, NTRK2 is linked to amyotrophic lateral sclerosis.