On the contrary, activating MuSK with an antibody treatment preserves NMJ innervation in ALS [186,187,188,189], although there are dissenting results between lack of MN survival and NMJ preservation and motor activity and life span enhancement in ALS mice that could be attributed to the differential methodologies used, and they manifest the need for further investigation to find an effective therapy for ALS. Here, MUSK is linked to amyotrophic lateral sclerosis.