When the study participants were stratified only according to their periodontal status and not by their weight, IL-1Ra and IL-8 concentrations were higher in those with medium or high risk (CRS II and CRS III, p < 0.001) of periodontitis, whereas IL-10 and TNF-α concentrations were lower when compared to those with the low risk (CRS I). This evidence concerns the gene TNF and periodontitis.