For instance, the medicago flotillins 2 and 4 (FLOT2 and FLOT4) and the soybean FW2.2-like 1 (FWL1) microdomain-associated proteins, are quickly translocated to the RH tip in response to rhizobia inoculation to promote RH infection [20,21,22,23,24]. Here, FLOT2 is linked to infection.