KDR and cancer: Cancer cell-derived exosomal microRNA-25-3p (miR-25-3p) regulates the expression of vascular endothelial growth factor receptor 2 (VEGFR2), zona occluden-1 (ZO-1), occludin and claudin5 in endothelial cells to promote vascular permeability and angiogenesis, and subsequently enhances the migration of colorectal cancer cells [15].