TARDBP and amyotrophic lateral sclerosis: Approximately 90% of ALS cases are sporadic (sALS), whereas the remaining 10% are familiar (fALS) cases, with mutations identified in greater than 20 genes (including SOD1, TARDBP, FUS, and C9ORF72) across varies cellular functions; these mutations contribute for the two-third of fALS and for about the 10% of sALS [106].