IGF1 and amyotrophic lateral sclerosis: Together with pharmacological administration of molecular inhibitors, injections of viral genomes were used to easily pass the blood brain barrier (BBB) and efficiently deliver genes in ALS mutant mice: for instance, after delivering IGF1 genes in SOD1G93A, the increase in IGF1-positive MNs is observed in the spinal cord, followed by an increase unbroken axon number, and reduction in neuroinflammation (astrogliosis) and in muscular atrophy.