Indeed, Le Pichons and colleagues (2017) confirmed an age-dependent increase in phosphorylation of JNK and c-Jun in neurons of the spinal cord (especially in lumbar portion) and in the cortex of SOD1G93A and TDP-43A315T mutated ALS models, as well as in lysates from sALS patients, confirming the activation of this pathway. This evidence concerns the gene MAPK8 and amyotrophic lateral sclerosis.