TARDBP and amyotrophic lateral sclerosis: Application of SILAC on cellular models of ALS showed a disturbed interaction of mutant FUS with survival motor neuron protein (SMN) and U1-snRNP, and the interaction of TDP-43 with numerous proteins such as ras GTPase-activating protein (G3BP), polyadenylate-binding protein 1 (PABPC1) and eukaryotic translation initiation factor 4A1 (eIF4A1) and hnRNP [111,112,113].