Tsalik et al. [51] emphasized the importance of NLRP3-inflammasome activation in sepsis survivors, supported by increased expression of the genes downstream from inflammasome activation, including IL1R2. Few studies show the role of various drugs that mediate their effects by regulating macrophage polarization and NLRP3 inflammasome activation [52]. Here, NLRP3 is linked to Sepsis.