To understand the biological meaning of the six upregulated DEGs (ARG1, IL1R2, FCGR1A, MMP9, ELANE, MPO) identified by the KEGG pathway under the transcriptional misregulation in the cancer pathway and amoebiasis at the protein level, we constructed a PPI network for these six DEGs-encoding proteins with interactions that included 143 nodes and 142 edges, as shown in Figure 4. Here, IL1R2 is linked to amebiasis.