Subsequently, given the intertwining of the c-Met, EGFR and TP53 pathways, we addressed our efforts to determine both the gene- (c-Met, EGFR, TP53) and protein-expression status (c-Met and EGFR) of these targets in a TKIs-naïve NSCLC patient population, and correlate these different results with each other. Here, EGFR is linked to non-small cell lung carcinoma.