Expression of the lncRNA HOTAIR is directly regulated by HIF-1α binding to its HRE site, while MLL1 (a histone methyltransferase) and p300 (a histone acetyltransferase) are epigenetically enriched at the HOTAIR promoter under hypoxic conditions, suggesting that both MLL1 and p300 coordination, as well as HIF-1α, are involved in the regulation of HOTAIR under hypoxia in CRC [59]. This evidence concerns the gene EP300 and colorectal carcinoma.