ASCL2 and colorectal carcinoma: Under hypoxic conditions, Ascl2 overexpression by HIF-1α induces EMT by repressing miR-200b; however, since HIF-1α is a direct target of miR-200b, the HIF-1α-Ascl2-miR-200b axis allows regulatory feedback for CRC EMT-MET plasticity [46].