The same pigment was effective against neuroinflammation in mouse brain through the inhibition of mitogen-activated protein kinase (MAPK) and the activation of nuclear factor κB (NF-κB) [144], as well as against bladder cancer through the inhibition of the signaling of phosphatidylinositol-4,5-bisphosphate 3-kinase/Akt or protein kinase B (PI3K/Akt) [145]. Here, AKT1 is linked to urinary bladder carcinoma.