FASN and obesity due to melanocortin 4 receptor deficiency: Previous studies have shown that polyphenols from LC can ameliorate the metabolic alterations that occur in obesity by decreasing oxidative stress and mitochondrial dysfunction and modulating the expression or activity of some proteins involved in metabolic homeostasis and energy control, such as peroxisome proliferator-activated receptor alpha (PPARα) and fatty acid synthase (FASN) [14].