Regarding CK5, Dairkee and colleagues reported for the first time the possible poor survival or early recurrence associated with the expression of CK5 in tumor cells in 1987 [43] and, although the functional role of the CK, such as CK5, CK14, or CK17, is still unknown, their expression is clearly associated with poor prognosis. This evidence concerns the gene KRT14 and neoplasm.