Noteworthy, we also showed that the constitutive phosphorylation of STAT3 on Tyr705 increased when CLL cells were cultured for 24 h in the presence of BMSCs (Medium alone 0.76 ± 0.17 vs. BMSCs 1.68 ± 0.15; Wilcoxon matched-pairs test, p = 0.0156) (Figure 2C,D). This evidence concerns the gene STAT3 and B-cell chronic lymphocytic leukemia.