STAT3 and B-cell chronic lymphocytic leukemia: Interestingly, we also found a constitutive STAT3 phosphorylation on Tyr705 as compared to normal B lymphocytes, in 86% of patients (Median Fluorescence Intensity (MFI): Normal cells, N = 6: 46.50 ± 6.12 vs. CLL cells, N = 25: 211.3 ± 35.85; Mann–Whitney test, p = 0.484, WB: Normal cells, N = 13: 1.11 ± 0.13 vs. CLL cells, N = 59: 1.56 ± 0.10; Mann–Whitney test, p = 0.0269, Figure 1G,H).