We observed that AG490 was able to trigger a time- and dose-dependent apoptosis in CLL cells, as shown by Annexin V/PI tests and the cleavage of PARP by WB (Figure 3A,B), and the down-regulation of Mcl-1 and Bcl-2 proteins (Figure S4A). This evidence concerns the gene BCL2 and B-cell chronic lymphocytic leukemia.