When we further examined the effect of Btz and the other DHPs on other types of cancer cells, we found that Btz/Amlo, Btz/Nigul, Btz/Nicar, and Btz/Felo induced cell death in SNU-668, NCI-H460, and BxPC-3 cells (Figure S2A), but with less synergism than seen with Btz/Ler (Figure 1B and Figure S2B). This evidence concerns the gene CASC3 and cancer.