In ER positive samples that did not present tumor downstaging, 49 gene sets were found in the GSEA analysis (FDR < 0.25) including one KEGG gene set, i.e., ECM receptor interaction (including five types of integrins, six collagens, four laminins, one fibronectin, and one trombospondin); eight GO gene sets; (biological process) cell adhesion; cell recognition; embryonic development; (cellular component) cortical cytoskeleton; cell projection part; cell surface; cytosolic part; and (molecular function) oxidoreductase activity (Table S12). This evidence concerns the gene FN1 and neoplasm.