Using a more stringent FDR value (<0.1), tumor downstaging was correlated with one KEGG gene set, i.e., antigen processing antigen presentation (comprehending CD74, CD8A, CD8B, and nine molecules of HLA complex, among others) and four GO gene sets (biological process), including one related with immune response, i.e., regulation of T cell activation (comprehending genes such as ZAP70, LCK, CD24, CD47, and CD3E, among others). The gene discussed is CD3E; the disease is neoplasm.