Using microdissected stromal cells, from samples collected before the start of neoadjuvant chemotherapy, we could identify eight genes more expressed in tumors presenting downstaging, including three genes involved in abnormal cytotoxic T cell physiology, such as TOX, LY75, and SH2D1A. In addition, gene sets correlated with tumor downstaging were mainly related with immune system pathways. Here, TOX is linked to neoplasm.