Regarding hormone secretion, invasive tumors are more frequently non-functioning, silent corticotroph and silent subtype-three PAs (now defined plurihormonal PIT1-positive adenomas, according to the most recent WHO classification [21]), or PRL-secreting and GH-secreting [22,23,24,25,26,27,28,29,30]. The gene discussed is PRL; the disease is gonorrhea.