Tumors with loss of FGFR2 expression and presence of a truncated isoform of FGFR4, the pituitary tumor-derived FGFR4 (pdt-FGFR4), confer invasive growth of pituitary tumor cells and contributes to downregulation of N-cadherin expression [157,158]. This evidence concerns the gene CDH2 and pituitary tumor.