For example, the first phase I trial evaluating the safety profile of human dendritic cell-derived exosomes (DEX) loaded with the Melanoma-Associated AntiGen 3 (MAGE-3), in MAGE-3 expressing melanoma patients, showed a good toxicity profile (no adverse events greater than grade 2), some clinical effect in 1/3 of the patients, and an increase in Natural Killer (NK) cells [183]. This evidence concerns the gene MAGEA3 and melanoma.