EPAS1 and neoplasm: In addition H/SB3 cells showed up-regulation of c-myc protein levels and reduction of p21 and p53 protein levels (Figure S7A,B), events reverted by HIF-2α silencing (Figure S7C), thus supporting the involvement of HIF-2α in the regulation of cell cycle regulators (p53 and p21) and tumor progression (c-myc).