Here again, statistical analyses on HCC nodules revealed a positive correlation (Spearman r coefficient = 0.4512, p < 0.05) between HIF-1α and HO-1 transcript levels (Figure S3E), with the highest levels of HIF-1α transcripts detected in HCC nodules characterized by higher levels (> than median value) of HO-1 transcripts (Figure S3F). This evidence concerns the gene HIF1A and hepatocellular carcinoma.