VEGFA and neoplasm: Moreover, by performing tubulogenesis assay on HUVEC cells treated with either hrSB3 or conditioned medium from H/SB3 cells (CM-H/SB3), we found that SB3 was able to induce tubes formation (Figure 8E, human recombinant VEGF used as positive control), indicating that SB3 can act as a paracrine mediator able to favor angiogenesis in the tumor microenvironment.