HMOX1 and hepatocellular carcinoma: Interestingly, immunohistochemistry analyses performed on liver serial sections from both SB3-TG mice and SB3-positive human HCC specimens (in comparison with specimens from normal liver, Figure S1), showed an intense staining for HIF-1α in the same tissue areas positive for heme-oxygenase-1 (HO-1) (Figure S2A,B), known to be up-regulated by HIF-1α through ROS [25,26].