Based on this strategy, many mimetics targeting cancer-related PPIs were discovered using virtual screening, such as p53 mimetics for the MDM2–p53 interaction [15,16,17,18,19,20], BH3 mimetics for the Bcl-2–BH3 interaction [21,22,23,24,25,26], and SMAC mimetics for the IAP–SMAC interaction [1,27,28,29]. The gene discussed is TP53; the disease is cancer.