ABCC3 and paracoccidioidomycosis: It was found that pharmacological inhibition of 5-LO in mice markedly ameliorated PCM-induced liver injury while inhibition of 5-LO induced hepatoprotective effect, which was associated with induction of the antitoxic phase II conjugating enzyme (sulfotransferase2a1), suppression of the pro-toxic phase I (CYP3A11), and reduction of the hepatic transporter (MRP3).