TFF3 and rheumatoid arthritis: With regard to the relation of OA and RA, the relative protein concentration of TFF3, there was a significantly lower (1.4-fold) upregulation in RA samples (4083.9 pg/mg, ranging from 2051.8 to 8413.0 pg/mg) than in OA samples (2833.9 pg/mg, ranging from 1730.8 to 4828.8 pg/mg) (Figure 3D and Table 4).