It was also shown that STAT3 binds to the promoter of the tyrosine phosphatase SHP-1 and recruits DNMT1 and HDAC1 to silence its transcription in cutaneous T-cell lymphoma (CTCL) and in ALK+ ALCL cell lines [57]. The gene discussed is DNMT1; the disease is primary cutaneous T-cell non-Hodgkin lymphoma.