ATF6 and Insulin resistance: Furthermore, the down-regulation of GLUT4, MEF2A, and PGC-1α were also achieved by overexpression of ATF6 and silencing ATF6 completely prevented glucosamine or Thapsigargin-mediated inhibition of GLUT4, MEF2A, and PGC-1α gene expression suggesting the role of ATF6 arm of the UPR in insulin resistance [89].