A statistical analysis of disturbances in the genotypes and alleles of the c.803 + 221C > A – TPH1 (rs1800532) polymorphism confirmed that the C/C and A/A homozygotes were linked with an increased frequency of stroke occurrence by 20 times, while the heterozygote of the same SNP showed a protective character and reduced the risk. This evidence concerns the gene TPH1 and stroke disorder.