TPH1 and Stroke: We also confirmed that the G/G-C/A and G/A-C/A combined genotypes of c.*456G > A (rs10988134) – KAT1 and c.803+221C > A – TPH1 (rs1800532) were related with a decreased risk of stroke, but the G/G-A/A and G/A-C/C combined genotypes of the same polymorphism increased this risk.