We found that the G/C-T/T, C/C-T/T and C/C-T/A genotypes of c.-1493G > C – IDO1 (rs10089084) and c.-1668T>A – TPH1 (rs623580) reduced the risk of stroke, whereas the G/G-T/A genotype increased this risk. Here, TPH1 is linked to Stroke.