Interestingly, the presence of the T/T-G/G and C/C-G/G combined genotypes of the c.975-7T > C– KAT2 (rs1480544) and c.-844G>T – TPH2 (rs4570625) polymorphisms elevated the risk of stroke development more than 30 times (p = 0.001). Here, TPH2 is linked to Stroke.