TPH1 and Stroke: Moreover, the frequency of the G/G-C/A and G/A-C/A genotypes of the c.*456G > A (rs10988134) – KAT1 and c.804-7C > A – TPH1 (rs1799913) combined polymorphisms was decreased in the patients after a stroke as compared to the controls by about 12 times (p < 0.001) and 25 times (p = 0.002), respectively.