The G/G-C/C, G/A-C/C combined genotypes of c.*456G>A (rs10988134) – KAT1 and c.-1449C > A – TPH2 (rs7963803) were linked with elevated occurrence of stroke, while the G/G-C/A genotype of the same polymorphism combination decreased this risk more than thirty times (p < 0.001). This evidence concerns the gene KYAT1 and Stroke.