Moreover, we observed that the C/C-C/C combined genotype of the c.803 + 221C > A – TPH1 (rs1800532) and c.-1449C > A – TPH2 (rs7963803) polymorphisms were associated with an increased risk of stroke, whereas the C/A-C/A genotypes reduced the risk. The gene discussed is TPH2; the disease is Stroke.