There was a link between an increased risk of stroke and the frequency of the C/C-C/C, A/A-C/C genotypes of c.804-7C > A – TPH1 (rs1799913) and c.-1449C > A – TPH2 (rs7963803), while the C/A-C/C and A/A-C/A genotypes reduced this risk. This evidence concerns the gene TPH1 and Stroke.