The T/T-T/T, C/C-A/T, C/C-T/T combined genotypes of c.975-7T > C– KAT2 (rs1480544) and c.-173A > T – TPH1 (rs10488682) were linked with an increased risk of stroke occurrence, while the T/C-T/T genotype of the same polymorphism combination decreased this risk. This evidence concerns the gene TPH1 and Stroke.