In this study, we demonstrated the production of targeted upconversion photoluminescent nanoconjugates UCNP@SiO2-LPG-MIL-38 for photodynamic diagnosis of bladder cancer cells and assessed their selectivity and molecular specificity towards Glypican-1 positive urothelial carcinoma cells T24. The gene discussed is GPC1; the disease is urothelial carcinoma.