In the microsatellite stable patient cohort, tumor protein 53 (TP53) and catenin beta 1 (CTNNB1) were more commonly altered in EO-CRC while adenomatous polyposis coli (APC), Kirsten rat sarcoma virus (KRAS), BRAF and family with sequence similarity 123B (FAM123B) were more commonly altered in LO-CRC. The gene discussed is AMER1; the disease is colorectal carcinoma.