Along with MCPIP-1 induction, the up-regulation of PERK and CNX in RCC cells and xenograft tumors by MCP-1 treatment may sensitize RCC cells to ER stress-induced apoptosis by facilitating the propagation of ROS signals through enhancing MAMs and by forming Bap31-containing pro-apoptosis complex, respectively. The gene discussed is EIF2AK3; the disease is renal cell carcinoma.