Furthermore, Heather Friberg et al. [137] extensively characterised the activation of dengue specific CD8 T-cells and showed that some heterotypic epitope variants showed an atypical mono-functional CD8 response characterised by MIP-1b release, whereas other heterotypic variants of the same epitope and the homotypic variant were associated with a polyfunctional response (MIP-1b, degranulation, TNFα, IFNγ) [137]. This evidence concerns the gene TNF and dengue disease.