DMRT1 and disorder of sexual differentiation: Deletions of chromosome 9p that include the DMRT cluster have been described in 46,XY DSD patients with dysgenetic testes [124] and overexpression of DMRT1 in the gonadal ridges has been shown to induce testicular differentiation and male sex development in transgenic XX mice [123,125], but SRY-negative 46,XX DSD attributable to DMRT1 upregulation has not been described in humans.