TGFB1 and hypertensive disorder: Thus, a low expression of IL-10 has been related to the polymorphisms in the IL-10 gene (−1082 A/G, −819 T/C and −592 A/C) in patients with hypertension, myocardial infarction and coronary artery disease [10,25,26].TGF-β is a cytokine widely distributed throughout the body.