Notably, reduction in adiposity, atherosclerotic lesions, and monocyte chemoattractant protein-1-(MCP-1) in control and LDL receptor Knock Out (KO) mice overexpressing hPON3 also suggests synergy of PON3 in obesity control and atherosclerosis [72]. Here, CCL2 is linked to obesity due to melanocortin 4 receptor deficiency.