In spite of PON3 promoter gene sequencing or numerous case-control studies aiming to determine ability of the variants to protect LDL from oxidation, rarely any of the variants had demonstrated an influence over gene expression to date except in one or two studies [50,52], with no conclusive results about PON3 association with CAD risk as summarized in the Table 1. Here, PON3 is linked to coronary artery disorder.